What causes infection
Infections start mostly from cuts and injuries that drop skin health below 80. Being sick above 85 can also infect the abdomen, and radiation sickness above 9 Gy can start random infections. The infection grows in the limb and is revealed at 25%, as a moodle and a cyst icon that turns purple as it worsens. Your character shows faint green stripes, then purple ones, on the infected limb. A rose light shows infections earlier.
Prevention is cheap: bandage every wound back above 80 skin health. That alone stops most infections.
Infection stages
| Moodle | Infection | Effect |
|---|---|---|
| Infection | > 0% | The limb stops healing skin and muscle; pain grows at infection / 10 |
| Painful infection | > 40% | Limb pain 4 or more |
| Severe infection | > 60% | Pain 6 or more; muscle starts dying above 75% |
| Life-threatening | > 80% | Pain 8 to 10; spreads to neighbouring limbs above 90% |
Each infected limb also raises body temperature by 0.02°C per second up to 40.5°C, so a bad infection costs you water and can push you into hyperthermia.
Disinfectants and how to make them
| Item | INT to craft | Notes |
|---|---|---|
| Sterilized dressing | 7 | Stops bleeding and disinfects at once |
| Spray bottle | 7 | Holds the liquids below |
| Relief cream | 9 | Best spray; also eases pain |
| Antiseptic | 9 | Standard spray |
| Antiseptic mush | training recipe | From popskin; buffed in demo 7.0, fits in medkits |
| Alcohol | found | Disinfects but hurts |
| Glowplant fruit | found | Makeshift antiseptic |
A disinfected limb is protected and its infection stops growing, unless your immunity is very low. Reapply as the effect wears off. Community wiki
Immunity
Immunity decides whether an infection shrinks or grows. It drops with hunger, cold, sickness (up to -80) and radiation, and rises with heat (up to a fever), antibiotics and a last stand. At 196% immunity every infection slowly clears by itself.
Sepsis
Sepsis builds when your total infection across all limbs is above 100: one 100% limb, or two 50% limbs. It also comes from injecting human blood (that kind fades by itself). Sepsis lowers blood pressure, stamina and maximum oxygen.
| Moodle | Sepsis | Effect |
|---|---|---|
| Sepsis | > 10 | Up to -30% stamina, less oxygen, wakes you from sleep above 35 |
| Severe sepsis | > 50 | About -36% max oxygen |
| Septic shock | > 80 | -58% to -72% max oxygen; breathing stops above 99 |
Fix: get total infection below 100 by disinfecting or amputating. Antibiotics and antiserum slow sepsis. A last stand cuts septic shock by 60%. Low pressure from sepsis can start fibrillation, so watch the heart.
Amputation
Drag a blade onto an infected limb in the health panel to start the amputation minigame. Valid tools include the flimsy knife, crude cleaver, metal sickle, machete, titanium machete and titanium multitool. Side-to-side wobble hurts and causes bleeding. Afterwards the stump bleeds heavily, so have a dressing and tourniquet ready.
Release 1.0 made amputation less punishing, allowed it on non-infected limbs, and allowed losing both legs. Lost limbs are no longer permanent: prosthetics come in 3 tiers, and the highest is better than a normal limb. Worn items on the limb drop instead of being deleted. Official Official
Questions
How do you make antiseptic in Casualties: Unknown?
Relief cream and antiseptic can be crafted from scratch at INT 9. Put either one in a spray bottle (INT 7) and spray the limb. Relief cream is the better of the two. Antiseptic mush, crafted from popskin, is a cheaper training recipe.
Do glowplant fruits cure infection?
They work as a makeshift antiseptic and disinfect the limb, which helps when you have nothing else. They are also a light source you can throw.
What is a good immunity level?
Normal immunity is 100%. At 196% and above every infection clears on its own, and the Leukocyte Overflow achievement needs 200%. Antibiotics, heat and good food raise it; cold, hunger, sickness and radiation lower it.
Does amputation stop infection?
Yes. Cutting off a badly infected limb removes its infection from the total that drives sepsis. Since 1.0 you can amputate non-infected limbs too, and lost limbs can be replaced with prosthetics.
Sources
- Community wiki Infection and sepsis Scav Prototype / C:U wiki, checked 2026-10-03
- Community wiki Injuries (limb and body statuses) Scav Prototype / C:U wiki, checked 2026-10-03
- Community wiki Guide: Getting started Scav Prototype / C:U wiki, checked 2026-07-09
- Official Release 1.0 patch notes Steam news, checked 2026-11-09
- Official September progress update Steam news, checked 2026-09-15